1. Skin Grafting: Thin skin samples are obtained with skin grafting knives, and transferred to affected areas after removing epidermis superficially. It uses equal size of skin, very effective, but associated with color mismatch, graft rejection, graft shrinkage etc.
  1. Epidermal Grafting: Blisters are produced by suction at the donor site. The roof of the blister is cut and grafted onto the affected area after scrubbing the superficial skin. The procedure does not cause any scarring but is more time consuming, blistering may be painful and only very small areas can be treated using this method.
  1. Mini grafting/Punch grafting: Small punch grafts are implanted 3mm to 4mm apart within minute holes in the Vitiligo/Leukoderma area. This is the simplest procedure, effective, but has highest proportion of adverse effects, cobblestone effect being most common.

Important Note: It is important to note that since no cause is known, there is no permanent cure for Vitiligo/Leukoderma. The disease can be treated to achieve re-pigmentation of Vitiligo patches, but it cannot be cured from the root.